Secretory immunoglobulin A (sIgA) deficiency is a less known but a significant aspect of having good immunity and a well-functioning digestive system.
I’ve long been interested in sIgA’s role in health and wellbeing, and would like to shed some light on this subject based on my clinical experience and research. The importance of sIgA for effective immune defence is indicated by the fact that more sIgA is produced than all the other immunoglobulin classes combined.
Despite the importance of sIgA for health, it’s one of the least well-understood areas of immunology.
What is Secretory Immunoglobulin A (sIgA)?
The body’s mucosal surfaces such as those of the nose, throat, eyes and gastrointestinal tract (GIT) are a large point of entry for various pathogens and thus must be well protected by the body.
The primary antibody/ immune system response to these irritants at the mucosal level is sIgA produced by the B lymphocytes (immune system cells) present in all mucosal linings.
The immune system responds to the protein component (antigens) of these invaders by producing large quantities of specific antibodies, including sIgA. These antibodies bind to the antigens on the surface of an invader (bacteria, for example) and prevent them from multiplying, thus halting the spread of disease in the body.
This mechanism works well when the GIT is healthy and sIgA levels are normal.
The daily production of sIgA is weight and age dependent with the maximum production level being reached at the age of 7-10 which then declines with age, especially after 60 years of age. It’s been calculated that around 60 mg of IgA is produced per kilogram of body weight per day in the average human, mainly in the mucosal surfaces of the body. These surfaces, which collectively have a surface area in adult humans of around 400 m2, are major sites of vulnerability, given their exposure to the environment.
We know from research that even a relatively short-term sIgA deficiency due to acute stress predisposes a person to the development of food intolerances or sensitivities, or to being susceptible to having pathogens in the GIT. When sIgA is low or lacking, absorption of food particles and microbial antigens increases dramatically making the GIT increasingly susceptible to infection.
People with food sensitivities, and especially food intolerances or allergies, have low levels of sIgA making them particularly susceptible to gut damage and increase in immune response reactions. sIgA ‘tags’ food as acceptable or not, so low sIgA leads to increased sensitivity to foods.
Causes of low sIGA
Medical research suggests that sIgA deficiency can be the result of genetics i.e. it’s an inherited disease that is passed from parent to child.
Some people can also have a partial sIgA deficiency which isn’t genetic and is caused by environmental or lifestyle factors such as;
- Poor diet
- Nutrient deficiencies
- Certain drugs (including anti-inflammatories)
- Viruses and impaired immune function
- Excessive stress
The good news is that the environmental and lifestyle factors can be reversed by identifying and addressing the cause(s) via better diet, tailored supplements and lifestyle modifications, as discussed below.
Low/ reduced sIgA levels
These are commonly seen in individuals with:
- Depleted immune system
- Food intolerances, allergies or sensitivities e.g. present in people who are “reacting to everything”
- Small intestine bacterial overgrowth (SIBO)
- Chronic Candida or small intestine fungal overgrowth (SIFO)
- Coeliac disease
- Inflammatory bowel diseases – ulcerative colitis, Crohn’s disease
- Parasitic infections
- Stress – several studies link stress and negative emotion with low levels of sIgAs. Secretion is adversely affected by stress which is mediated by cortisol produced by the adrenal glands. Therefore low sIgA levels are often present in burnout/ adrenal fatigue/ adrenal exhaustion when cortisol levels are low.
High/ elevated sIgA levels
May reflect the following:
- An activated immune response to chronic infections including viral infections such as EBV (Epstein–Barr virus), CMV (Cytomegalovirus), HIV, and/ or inflammatory reactions.
- High level of sIgA may also indicate an infection of the digestive system or inflammatory conditions such as Crohn’s disease or ulcerative colitis.
It’s thought that the initial immune response to the pathogens or inflammation is an elevation in sIgA, followed by its depletion with continued exposure to irritants. Dysregulation of this immune function has also been implicated in autoimmune and chronic inflammatory conditions.
Symptoms of sIgA deficiency
Many people with sIgA deficiency are asymptomatic. It’s not understood why some individuals with sIgA deficiency have almost no complaints while others are quite sick.
Those who do have symptoms typically have recurring ear, sinus, or lung infections that may not respond to regular treatment even with antibiotics.
Other problems include multiple food intolerances/ sensitivities or allergies, coeliac disease, asthma, chronic diarrhoea, and autoimmune diseases such as lupus and rheumatoid arthritis.
Since sIgA serves to protect the gut, lower levels can also lead to an increased risk of ‘leaky gut’ (or increased intestinal permeability), dysbiosis or SIBO.
These food particles cause the body to react by creating other classes of immunoglobulins, primarily IgG, to protect the blood and tissues. A person with leaky gut may therefore have IgG reactions to many foods which can be detected in blood tests.
Testing
sIgA levels can be tested by performing a blood test measuring serum IgA, salivary or fecal sIgA tests. When measured via the comprehensive diagnostic stool analysis test, the reference range of sIgA is between 51 – 204mg/dL (Genova Lab range). Different labs use different ranges according to the type of test performed.
How to normalise sIgA levels
Conventional medicine doesn’t offer any particular treatment; however, there is much that can be done to balance out sIgA levels by following naturopathic medicine therapies below:
- Embark on a comprehensive gut treatment to repair and seal the gut wall involving correcting gut flora imbalances, decreasing food sensitivities, decreasing inflammation and restoring gut wall integrity.
- Eliminate food allergies and intestinal parasites – using medications and/ or anti-parasitic herbs and supplements. In clinical practice a combined approach is often quite effective.
- Enhance the immune function – using herbs, supplements, lifestyle modifications and stress reduction.
- Address any existing acute and/or chronic infections anywhere in the body – by testing the immune function, inflammation levels and other relevant parameters, and then embark on improving them with medications, supplements and herbs, as appropriate.
- Reduce stress – stress is particularly detrimental to sIgA levels and stressful events contribute to development of adrenal fatigue (exhaustion or burnout), worsen GIT function and food sensitivities in vast majority of people. Lower levels are found in those with excessive cortisol production which correlates with increased stress levels, so decreasing stress will lead to higher sIgA levels.
- Check for vitamin A deficiency – vitamin A is known for its protective roles against infections. An important part of the protective function is its ability to enhance antibody responses, especially IgA antibody responses in mucosal tissues. Adequate vitamin A from animal sources such as cod liver oil, combined with good quality probiotics, and sIgA support with Sacharomyces boulardii (S. boulardii) probiotic strain (which increases sIgA production) are important steps in restoring immunological health.
- Helpful supplements and foods include:
- Glutamine for gut wall repair (mainly small intestine)
- Fish oils and cod liver oil for reducing inflammation and presence of vitamins A and D (in cod liver oil)
- Chlorella (see the chlorella study published by the Nutrition Journal in 2012)
- Fermented foods, meat and bone broths
- Fibre to feed the good bacteria
- Other nutrients: choline, glutathione, glycine, phosphatidylcholine, vitamin C and zinc are all needed for efficient production of sIgA.
- Use specific probiotics that have been studied to date to increase sIgA levels including:
- GAPS diet or an elimination diet based on the IgG food sensitivities testing are effective strategies for healing the gut, normalising digestion, addressing nutrient deficiencies and reducing inflammation, among others.
Feel free to post a comment below if you have abnormal levels of secretory immunoglobulin A and would like to exchange ideas on potential natural solutions for this complex issue.
I update this post regularly as new information and studies reveal more about the role and importance of secretory immunoglobulin A for overall health. Consider subscribing to my newsletter to keep up to date (see the right side column of this blog to subscribe).
Please note that the above material is for informational and educational purposes only and is not intended as a substitute for medical advice, diagnosis, or treatment. Consult with your health practitioner or doctor for advice specific to your circumstances.
Best of Health
Joanna Sochan
Wholistic Health and Lifestyle Therapist
Natural and Lifestyle Therapies for Abundant Health and Wellbeing
sIgA image source: Dolphin Microbiology Group website
FREE Sleep Guide download
Sleep plays an important role in achieving and maintaining good levels of secretory immunoglobulin A!
Having seen many fantastic outcomes of improved sleep in my practice, I wrote a short free ‘better sleep’ guide for my clients. It comprises key practical tips based on my clinical experience and research, to give you the most important, common sense steps and actions you can do right now to get sounder and more restful sleep tonight.
This FREE Sleep Guide, in a form of an eBook, will provide you with the key tips and guidance to improve your sleep fast, especially if you’re struggling with fatigue, adrenal fatigue, anxiety or hypoglycemia.
Download your copy of the FREE Sleep Guide here: Top 3 Nutrition Tips for Better Sleep Tonight! Key nutrition tips for insomnia plus my top 3 bedtime snacks for deeper and restful sleep
Additional resources
- What is leaky gut? Causes, treatment, remedies
- Adrenal fatigue treatment: The Kalish Method Australia
- Parasite treatment considerations: Blastocystis hominis and Dientamoeba fragilis
- Drinking coffee – pros and cons from a medical perspective
- Histamine intolerance: causes and treatment
- Weight loss and food sensitivities: Karen’s story
Disclaimer: The above material is for informational and/or educational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical advice, diagnosis, treatment, prescription or recommendation. All viewers of this content, especially those taking prescription or over-the-counter medications, should not make any changes in their health regimen or diet before first consulting a doctor or other qualified health provider with any questions they may have regarding a medical condition or their particular circumstances.
Joanna Sochan is a Natural Therapist and founder of Naturimedica Holistic Wellcare. She has a passion for helping clients transform their lives by becoming healthy and well naturally. Joanna has 12+ years experience in clinical practice and has special interest in solving complex cases, functional medicine testing, gut health, sleep, fatigue and chronic pain. She guides clients through her tailored programs and eCourses as well as helping them individually (mostly online) Australia-wide. View full bio.
Print This Post
Hi Joanna! This is so helpful! Thank you for your amazing work. I did a stool test as I am experiencing debilitating eczema mostly surrounding my mouth and eyes (and a bit on my ears). My results showed some issues…
*High fecal secretory IgA (487 mcg/g)
*High Beta-glucuronidase (5,077 u/g)
*Potentially pathogenic bacteria present (6 bacterias in the very HIGH range)
*Low diversity of bacteria
*Low Firmicutes/Bacteroidetes Ratio
From your articles, I can tell that this is consistent with a virus potentially effecting my detox organs resulting in Eczema? This information is helpful, but I don’t know where to go from here!
Sending love from CA!
Hi Marcia
Thank you for your comment. I find that eczema highly correlates with gut dysbiosis (imbalances in good/bad bacteria) allowing the pathogenic bacteria to overgrow in the gut and produce excessive toxins that overwhelm detox organs (kidney, lungs, gut and skin). In such cases it’s best to focus on re-balancing the gut using specific probiotics, prebiotics, gut supporting supplements and supportive nutrition. I suggest you work with a natural medicine professional to help you with proritising the issues to tackle them successfully.
Hi Joanna. I have chronic constipation as my primary symptom. My GI MAP showed a SIGA >6000, anti-gliadin >500 and elevated b-glucuronidase. Any suggestions?
Hi there
I suggest you see a qualified natural medicine practitioner for evaluation and discussion about potential root cause(s) of your symptoms.
Dear Joanna,
My daughter has many gynecological problems (policystic ovaries, irregular periods, painful periods so that she is vomiting) and acne.
She has calprotectin 59 (normal is less than 50), lactoferrin 36 (normal is lower than 7), extra high secretory IgA 26.000 (normal is less than 2000), normal EPX, normal pancreatic elastase, normal anti-tripsin, normal total fat, zonulin 100 (normal is less than 100), giardia and dientamoeba (but just in transit, not parasitosis). She has low lactobacillus, high E. Coli, low pseudomona, extremel low Saccharomyces cerevisae, low colic acid and a little bit low SCFA
Do you have any idea what could be the reason of a such a high inflamation?
High IgA can indicate some sort of inflammation in the body (like higher calprotectin in the gut but there may be other inflammation going on anywhere in the body). For example, it could be ongoing infection or significant food intolerances. Also, there are gut flora imbalances you mentioned that will cause IgA to elevate.
So, I suggest further investigations along the lines I mentioned above.
I just did the Genova comprehensive GI effects. It only showed 2 things. 1) I have no Lactobacillius 2) I have a high IGa of 1170 What could cause the high IGa with nothing much else abnormal in the test?
High sIgA can indicate a heightened immune response instead which usually signifies some sort of inflammation in the body. It will generally be an acute immune response, ongoing infection, or significant food allergy.
If elevated SIgA levels have been found in the absence of bacteria, candida and parasites imbalances/ infections in tests, it can indicate significant atopic conditions like food allergies, urticaria (hives) or eczema.
Do any of these ring a bell in your case?
After a mild diverticulitis attack in July (first one), I am still ill, nausea/fatigue coming in bouts of several days, even after taking the antibiotics. The Genova GI Effects test my doctor ordered showed no infections, or parasites or H pylori and was what my doctor said was a great test result but said to take more probiotics. But it showed a high SigA of over 2850 (normal is below 885). That test was taken in early September. So it is two months since I finished the antibiotics for the diverticulitis and I am still having multi-day bouts of nausea, fatigue and depression. Stools become a little scarcer during these bouts but cannot say it is either diarrhea or constipation. I have been taking high-quality probiotics, eating fermented vegetables, taking Biocidin and Oregano oil capsules, no alcohol, no coffee, and otherwise eating a healthy diet. What would you recommend to do next?
I suggest the next step would be to undertake a microbiome restoration treatment and correct the microbial imbalances identified in your GI Effects test. This is done with specific foods promoting good bacteria found to be low on the test, tailored prebiotics and specific probiotic strains, depending on your test results (such as Lactobacillus rhamnosus GG for example). I don’t know specific details of your protocol but if you’re currently taking probiotics/ eating fermented foods AND taking both Biocidin and oregano oil – which are strong antimicrobials, you’re not rebuilding your good flora much as these supplements decrease/ kill both good and bad bacteria. Therefore microbiome restoration treatments I recommend don’t include antimicrobial herbs.
I did a Genova comprehensive stool kit and my Secretory IgA levels were 2952 and the range is supposed to be <=885mcg/g. As well as slightly elevated EPX. I started having issues when i was diagnosed with SIBO from antibiotic use. Before that i had zero digestive issues. I have don't 3 years of constant treatments, with nothing having improved. I have no idea what to do anymore as most doctors give up on my case. I have seen traditional gastro's, natural medicine doctors as well as a functional medicine; a year with each one before finally feeling as if there is zero hope left. I have severe constipation since this started that no one can seem to figure out. Even an ER enema failed. Any tips?
There’s always hope and options so keep going and searching for clues and solutions! In cases like these I recommend doing comprehensive gut testing such as GI Map / GI Effects / Ubiome tests to map out your microbiome and see what bacterial imbalances you have that are likely causing the symptoms, and then correct them by developing and implementing a microbiome restoration program. You’ll need to work with an experienced gut specialist to do this.
Hi! I have had secretory IgA tested (stool) and it was 87.1 (51-204 Mg/dL), is this consired too low even if it is in range? My test didnt show any parasites just low good bacteria. Should I be concerned about possible underlying causes still? Thank you for a good article!
It’s good that your levels are within the range and you don’t have major symptoms (I presume from your short description). If this is optimal for you depends on your overall gut and immune system health. Also, lower sIGA could be due just to too much stress. Consider adding probiotic S.boulardii as part of your treatment for low good bacteria, it’ll help both increase sIgA and supporting the goof bacteria.
Thank you for replying! Is S.Boulardii safe to take for long term? I do take probiotics daily(PB8, Healthy Origin) I have been and still am working on trying to reduce stress.
Yes, S.boulardii can be taken long-term i.e. 3-6 months+ as part of gut protocols. It’s been prescribed for several decades to treat various gastrointestinal conditions Most supplements contain 250 mg (or 5 billion CFU) of SB per capsule and recommended therapeutic dose is 4 caps per day (2 caps with breakfast and 2 with dinner). I usually suggest starting with 1 cap 2xday for a week or so and then increasing to 3-4 per day depending on a client.
Hi,
I have chronic EBV and possibility co infections. I just got results on High SIgA numbers. I was wondering what steps I can take to equalize these and bring the numbers down.
First of all you’ll need to establish which infections are present and remedy them, plus also improve your gut health by undergoing a gut repair program. You’ll need to test the gut function (Complete Digestive Stool Analysis test) to establish what’s going on in there.
Hi! Thanks for this article! I have been struggling with colitis off and on for 9 years now. I had a remission period for almost 2 years and it’s stsrting to flare up again. Also was diagnosed with Uveitis eye disease in October. I had the Genova stool test done a year ago. Just dug it out to look again. I have high levels of calprotectin, EPX, secretory IgA, positive Fecal Lactoferrin, and high fecal fats. Also had klebsiella. Any thoughts of what I could do to help heal myself? Thanks!
As there are multiple layers of conditions and symptoms, I suggest you seek help from a practitioner whom specialises in gut disorders. You’ll need to prioritise the steps in the treatment and follow them consistently and persistently, modifying diet, taking supplements and making lifestyle changes as well. Are you in Australia?
Hi Joanna, my stool test (Genova GI Effects) revealed very high secretory IgA levels – 1805 mcg/g (normal levels should be <= 885 mcg/g). The test also revealed mildly elevated Eosinophil Protein X (EPX) levels and normal (low) Calprotectin levels. There were no infections identified – no pathogenic bacteria, no parasites, no yeasts. Do you know what could be causing the high secretory IgA? Maybe some hidden food allergy or sensitivity?? Any suggestions? Thank you.
I suggest you do blood testing to exclude chronic infections including viral infections such as EBV (Epstein–Barr virus), CMV (Cytomegalovirus), among others. Food sensitivities/ intolerances cause inflammatory reactions as well and need to be investigated here.
Thank you for replying Joanna. What tests would you recommend for food allergies/sensitivities and intolerances?
Best regards
I find this test to be very good https://www.naturimedica.com/biocompatibility-food-testing-regain-your-health-by-eating-foods-compatible-with-your-body/, if you live in one of the countries where it’s available – check the post for details.
Hi, I have had a stool test done. Candida, leaky gut and parasite came back all ok. In fact they said my gut flora was pretty good. However my slgA level was low. 87 from the range of 510-2040.
Could this explain my fatigue and in particular my brain fog?
Hi Jasmine
Are you stressed? Low sIgA levels are often present in adrenal fatigue/ stress. Is your immune system working well? These are my top suggestions after reading your brief post.
I did the BioHealth Laboratories GI Map Test & Its results came as to be Infected with H-Pylori & Low Levels of Candida , But at the same time i have very Low sIgA levels about 20 . Would this Pathogens/Bacteria cause this very Low Secretory igA levels & how this could be boosted & Improved . I have constant bloating & cramps after every meals which my Functional Medicine Dr has indicated due to this H-Pylori & very Low levels of HCL . Whats the recommended diet plan
Yes, low IgA is connected with parasitic infections in the gut. I suggest you work with your functional medicine doctor to eradicate H.pylori and Candida to relieve/eliminate he bloating and cramps and increase HCl production via supplementation and diet. Also, talk to your Dr about your diet as it needs to be tailored for your condition.
Hi, my daughter has Hashimotos and 3 very high cortisol, constipation, food allergies, we think malabsorption of thyroid meds and supplements, high ferretin (low iron), and now the Genova GI effects test shows a secretary iga result of very high 1270. Her doctor seems at a loss. Do you have any recommendations to help figure this out?? We are desperate. Thank you so much in advance!!
I’m afraid I can’t offer specific advice via the blog but I’d suggest you look at inflammation levels in the body as well as the gut function which is almost always linked to Hashimnoto’s/ thyroid problems.
My friend takes laxatives every day, can’t this make her sign levels high and can this cause her to have leaky gut issues
Yes to both! Stool test would help your friend to determine what is causing her constipation.
My 13 year old daughter has been having multiple health issues including gall bladder attacks. Liver values and ultrasound were normal. DC wanted to rule out parasites(she was born in Guatemala). Diagno-Techs GI panel shows borderline low IgA of 15. No parasites and scant yeast. Stool culture shows Heavy growth of mixed Gm Neg and absence of Gram pos bacteria with no pathogenic bacteria noted. Chymotrypsin was also low. Gluten Ab (saliva) was positive even though she’s been on a gluten-free diet for over a year.
Any input would be appreciated.
Hi Karla
It sounds like there is gut dysbiosis present (imbalances between beneficial and problematic bacteria), also flagged by lower sIgA. Dysbiotic bacteria can also affect bile consistency making it more thick and thus affecting gallbladder function. I suggest you talk to your doctor about undertaking a gut cleanse and repair treatment with gallbladder support supplements and nutrients such as lecithin, among others, to help to dilute the bile and help with fat digestion.
Hi Joanna,
Thanks for your quick reply. I was told that the level of clostridium were not so much the problem, but to focus on the low IgA and low acidity. I will try to find someone to help, but I am not sure where to start.
For myself I was told to choose between a naturopathic and nystatin treatment. Could you tell me the difference?
Would you be available to talk on Skype?
Thank you very much for clarifying the questions and for your time.
Renata
Depending on circumstances, it’s possible to use both nystatin first followed by a comprehensive naturopathic treatment for optimal results. You’ll need to discuss this with your doctor/ naturopath, it’s not possible or appropriate for me to make any suggestions here.
Where are you based?
Dear Joanna,
I found your website quite interesting. I have been trying to find a solution for my son’s digestive problems since he was really young. He had colic, then reflux (vomiting for 4 months), then he developed Asthma. He is only 3,5 years old and I have tried all healthy food protocol. He takes probiotic, sauerkraut and vitamins every day. After a long search I did a stool test with him and found out his secreted IgA is <20, stool ph 6 and clostridium spec high. I was told he needs to improve the secreted IgA, but I would like to know exactly what he should take in terms of vitamins. I will try the GAPS diet, but it will be hard because I work full time. I would appreciate any help. Thanks.
Hello Renata
To increase sIgA in this case I suggest doing a comprehensive gut cleanse treatment to eradicate the clostridium bacteria and then rebalance the gut flora and digestion with probiotics, prebiotics and other supplements as indicated. GAPS diet would greatly help in this process but you may need to look into contacting an integrative GP who specialises in gut work to help with eradicating clostridium which could be challenging to treat. Sometimes antibiotics are needed followed by a naturopathic treatment.
Hi! I have just been told my IgA is increased 444, 44 above mark and Igg increased in a number of food items. My hscrp is also elevated to 7, instead of less than 1 to be normal but my ESR is normal. Is this heart attack/stroke risk of inflammation in gut? Used to have mild chronic gastritis fir years- could it be that? What should I do to know the source of inflammation? Thanks!
I suggest doing a complete digestive stool analysis test to start with, to see what’s going on there. There may be simple answer(s) to your problems once you know the results.
Very helpful, Joanna!
I read your link and do have the GAPS book. Have you found that the GAPS diet eliminates yeast/bacteria without the need for medication? I am also wondering if the SCD diet works in a similar manner? If my son had casein in his peptides, would you wait to introduce homemade fermented dairy? I am asking because it can feel very restrictive and he loves yogurt.
Thank you very much,
Jacqueline
Jacqueline
GAPS and SDC are similar and will both help with eliminating yeast and problematic gut bacteria in time. Sometimes antimicrobial herbs are used as well, depending on the person and their circumstances. It takes time to do it through the food alone but it is more a permanent solution as the yeast and bacteria are there because of the detox problems and accumulation of toxins in the body. As the toxins are removed via the diet, the yest will decrease and be kept under control by the immune system.
Regarding fermented dairy products, they are best introduced gradually following the dairy introduction structure as outlined on page 124 in the GAPS book. Some people need to wait to after the introduction diet is over and then introduce dairy (gradually).
Joanna
Hi Joanna,
My son has a secretory Iga of 510 (as well as dysbiotic flora, +3 enterobactoer cloacae complex) from his comprehensive stool and does show some yeast in his OATs test (arabinose of 158). Would that be a reason for high SIGA? I am trying to figure out if he has leaky gut. Could someone have leaky gut with a high SIGA? He is 6 years old and on the ASD and I am trying to help him get what he needs to feel better.
Thank you!
Hi Jacqueline
In this case high sIgA could reflect an activated immune response to some kind chronic infections such as viral or bacterial infections and also inflammation in the gut that is caused by them. It is thought that the initial (acute) response to these infections is elevated sIgA, which later drops with continued exposure to irritants. From my experience dysbiosis and presence of harmful bacteria pretty much indicates that the gut wall is damaged and leaky gut is likely.
Have you looked at the GAPS diet for your son? Here is the link to my post about it http://naturimedica.com/gaps-diet-what-is-it-and-when-to-apply-it-sydney-australia/. The diet or rather the GAPS nutrition protocol is used to repair the gut, eliminate parasites and/or harmful bacteria and normalise sIgA, among many others. It’s a long-term healing process (could be up to 2+years) that is done via specific nutrition changes and supplements but for many people is truly life changing.
All the best
Joanna
Hi Joanna,
Thank you for your answer.
Best regards from Poland :)
Bozena
Hi Joanna,
I have just received my son’s comprehensive stool analysis. That is why I was searching for an explanation of some results. The only problem I can see is secretory IgA 287 mg/dl and many fat stains. No parasides, no disbiotic flora. What would be the next step, what else shoul ai check (waiting for organix results and doctor visit schedulled for October but trying to find something in June/July.
I wander if you could suggest? Son is 4.
Hi Bozena
I would wait for the organic acids results to see what are the high markers there and then cross-check the two tests for clues/ further actions. Remember that CDSA test shows what’s happening in the LARGE intestine and organic acids test will indicate what’s going on in the SMALL INTESTINE (such as SIBO, dysbiosis, yeast overgrowth, clostridium bacteria etc) plus brain function, energy production, detox capacities including methylation, and B vitamins levels, among others – it’s such a great tool to identify root cause(s). You’ll need someone who can interpret the results correctly, though.
All the best
Joanna
I’ve just had a comprehensive stool test done and my sIgA levels were very low but no sign of leaky gut, Candida or parasites. My stool oh was 7.5.
I am unsure of the cause as it is conflicting to have such low levels without sign of Candida leaky gut etc. How would I increase my sIgA levels?
Hello there
Other main causes, apart from gut imbalances/ symptoms, of low sIgA include protein deficiency (not having enough or not able to digest protein properly), multiple nutrient deficiencies (especially zinc and vitamin A) and chronic illness. May be worth doing testing to check these three areas.
All the best
Joanna
Wonderful article!! Can you comment at all on the physiology found in a high sIgA from a Genova stool test and a low serum total IgA?
Hi Jonathan
It’s a big topic to cover! Plus any analysis and conclusions need to be done on an individual basis taking into account what else may be going on/ contributing to the picture.
All the best
Joanna
Could SIBO cause an elevated Sig A level? I have CVID with low IgG, IgA and IgM. I get IVIG every 3 weeks and have tested positive for SIBO on 2 different breath tests….but I do wonder if that SIBO is causing an elevated Sig A. Thank you!
I have tested high Sig A on the Genova test and also have tested postitive for SIBO on 2 different breath tests 2 years apart. Could the SIBO itself be the cause of the high SigA? I’m going to see a gastro/immunologist this week as I also have CVID and get IgG via IV every 3 weeks. I am low in all 3: IgG, IgA and IgM, hence the CVID diagnosis. With the low IgA I still have tested to have high Sig A. I believe this doctor uses Rifaximin to treat the SIBO as one TX approach. I just wonder if the SIBO has caused that elevated Sig A test…… Any thoughts….thank you so much!
Yes it can. SIBO causes gut flora imbalances, increases inflammation and loss of gut wall integrity, to name a few. So treating SIBO should help to balance sIgA levels.
All the best
Joanna
Hi Joanna —
Thanks for providing this service of consulting with people. I’ve had the Genova GI Effects test done and it shows I have high fecal secretory IGA (1,795 mcg/g). I often have symptoms which resemble histamine intolerance and SIBO, including pretty severe ear / nose / throat constriction / congestion and possibly overtaxed liver (yellower skin). My results also show high PP bacteria, low n-Butyrate, low diversity, absence of Verrucomicrobia, high bacteriodetes, low firmicutes, high klebsiella, and high citrobacter. Blood food allergy tests show low IgE and IgG (no allergies / leaky gut). My symptoms seem to be exacerbated by herbal antimicrobials, glutamine, and probiotics. Symptoms began after use of prescription antibiotics and subsequent probiotics / fermented foods. I do better with raw vegan fare. Considering going on xifaxin and nystatin (worked for me a year ago). Any thoughts as to what my clinical picture is and success stories for treatment in others with similar symptoms? My labs and responses to treatment seem to stump physicians.
Thanks,
Seth
Hi Seth
Thank you for your comment and detailed description of the labs. I suggest you look into possible excessive heavy metals accumulation to gauge which metals may be high and what are their side-effects. Also GAPS diet seems to be a good option here to re-balance the gut and drive out the nasty bacteria, have you considered it? Check out my post here to start with http://naturimedica.com/gaps-diet-what-is-it-and-when-to-apply-it-sydney-australia/
All the best
Joanna
Hi Joanna,
Thank you so much for sharing all this info. I am a little bit confused. I just took a Genova Gi effects stool test, my results are elevated “Fecal secretory IgA at 1,268” , but the normal range is “<=885 mcg/g ". Your normal range is 51 – 204mg/dL . Can you please help with this. I am very confused, and would love to know what I'm dealing with.
Thank you so much!
Hi Diana
It looks like the Genova Lab has changed the measurement units for the test from mg/dL (as per my post) to mcg/g hence the different ranges for the test interpretation. So it looks to me like your sIgA levels at 1,268 are elevated on the new scale.
All the best
Joanna
I’ve been suffering for over 20 years with symptoms of IBS. chronic diarrhea and bloating and cramping. I’ve been treated by several doctors over the years without much success. 4 colonoscopies done without a real diagnosis. I recently started see a nutritionalist who had stool testing done by a lab. My SIgA level is 818. Is that level high enough that I should see a MD about it or is just diet change and supplements sufficient to take care of what’s going on in my gut.?
Hello Sharon
Depending on what else was tested and the results, there can be a few natural options to follow and the nutritionist should be able to guide you how to decrease sIgA. You may consider to do the nutritional therapy for a while and see if it works for you – there are great supplements and herbs for the gut. If you decide to seek a second opinion by seeing an MD make sure that she/he is a functional/integrative type of practitioner who understands gut health.
All the best
Joanna
I just discovered this web site, and am looking forward to exploring it further and maybe even subscribing.
Hi Greg
I’m glad you’ve discovered and like my website and hope you’ll enjoy the content! You may also consider having a look at my Facebook and other social pages where I regularly post natural medicine updates and tips.
Thank you very much for taking the time to let me know about the broken link. I’ve fixed it now!
All the best
Joanna
I have been ill for just over 1 year. Respiratory Issues. My SIgA was elevated at 693. Any suggestions and could this affect my respiratory?
Hi there!
Thank you for your question. Yes, sIgA is produced in mucosal surfaces throughout the body including the lungs. High sIgA indicates possible presence of chronic infections and inflammation that is present there plus the gut as well. Have you done any lab test to pinpoint what’s going on in the lungs? It sounds like there may be a chronic infection going on there keeping you feeling sick – could be bacterial or viral, sometimes both. The tests (done via your doctor or naturopath) should be able to clarify this and help to decide where to commence any treatment.
All the best
Joanna
Hi, Joanna.
I recently received my Geneva results and my sIgA was 277 with a Reference range of <=885. Can you please make sense of this for me? Is this considered low or high on the Geneva test?
I also had very high fecal fats.
I look forward to your reply!!!
Hi Joanna, I had a comprehensive stool test done recently and it showed that my sIgA levels are very low and that I have a moderate Candida overgrowth in my gut.
If I understood correctly, chronic Candida overgrowth and/or gut dysbiosis can cause a big stress on our immune system and thus reduce sIgA levels. Is that correct??
I’m desperately trying to find out the root cause of my low sIga levels. I’m suffering with food sensitivities, chronic inflammation and IBS symptoms.
Hi Leonardo
Thank you for your comment. Yes, low levels of sIgA are strongly associated with the gut not working well because of conditions such as leaky gut, parasites, candida, SIBO, among others. Also, there is usually considerable gut and/or systemic inflammation happening as well to which the immune system reacts too. Please read my article on the GAPS diet for more information on gut/the immune system connection here http://naturimedica.com/gaps-diet-what-is-it-and-when-to-apply-it-sydney-australia/
I suggest you look for a naturopath or other qualified natural medicine practitioner who is experienced in healing the gut and adrenals to embark on a comprehensive gut repair and adrenal boosting programs to start addressing the low sIgA levels. This is the first step to gauge what else may be going on healthwise.
All the best
Joanna
Hello Joanna
Just want to thank you for such an amazing informative site regarding health issues. I shall certainly save your site for future queries about my health.
Regards
Lorrie
Hello Lorrie
Thank you very much for taking the time to comment, I truly appreciate it! I’m happy you found the information useful as I spend considerable time to research each article and make the information practical as well. You may consider subscribing to my monthly newsletter to keep up to date with my posts. Here is the link https://www.naturimedica.com/blog/
All the best
Joanna
Hi Joanna,
Could you tell me what a normal sIga level should be please?
Thanks
Kerry
Hi Kerry
Thank you for your question. I have now updated my post to include the sIgA reference range information.
When measured via the stool analysis test, the reference (normal) range of sIgA is between 51 – 204mg/dL (Genova Lab). It’s good to have the results towards the middle of this range but any result needs to be considered for each individual and their state of health.
All the best
Joanna
Hi
Firstly your article that I have read on sLga is the first that makes sense.
I can see that you are a herbalist, nutritionist and neuropath to which I’m hoping you will be able to help me with a condition leaky gut. I suffered with chronic fatigue ( brought about by doctors – massive doses of antibiotics and other life style issues – keeping it short)
However have now had a stool sample tested and results confirm elevated SLga and leaky gut immune responses. I real hope that you live close by?
If not do you do telephone conference calls?
I would very much like to discuss my health issues with you further and request your contact telephone numbers if possible assuming you still practise?
I await your response to this internal email
Kind regards
Gary Rutland
Hi Gary
Thank you for your enquiry. Where are you based? I’m in Sydney but also conduct Skype/ phone consultations, where appropriate. Please send me an email to info@naturimedica.com if you’d like to discuss this further.
All the best
Joanna